EPISODE 39: NEN TREATMENTS: FOCUS ON LIVER-DIRECTED THERAPIES
PART II: Intra-Arterial Techniques and Sequencing
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ABOUT THIS EPISODE
In this 2-part series, Dr. Osman Ahmed from University of Chicago covers liver-directed therapies for neuroendocrine neoplasms (NENs or neuroendocrine cancer). In this second episode, he details the embolization techniques including bland embolization (TAE), chemoembolization (TACE), and radioembolization (TARE, SIRT, y90). He discusses decision-making, sequencing, and follow-up after these procedures.
MEET DR. OSMAN AHMED
Osman Ahmed, MD, is an expert vascular and interventional radiologist who diagnoses and treats a wide range of conditions. Using image-guided technology and small, sophisticated instruments, Dr. Ahmed performs minimally invasive procedures for acute and chronic deep vein thrombosis, benign prostatic hyperplasia, peripheral vascular disease, liver/bone/lung/kidney cancer, spinal fractures, uterine fibroids and more. He also implants inferior vena cava (IVC) filters, which prevent a blood clot from traveling around the body or creating a blockage.
In addition to his clinical expertise, Dr. Ahmed researches novel treatment options that improve outcomes for patients. His research on liver cancer, IVC filters and venous diseases has been published in several high-impact, peer-reviewed journals, including the Journal of Vascular and Interventional Radiology, Radiology, Chest, Journal of American College of Radiology, and Journal of Surgical Oncology.
Dr. Ahmed also believes in the importance of educating medical students, residents, fellowships and peers in order to enhance health care across the world. He has been invited to speak at a number of symposiums, practicums and national/international meetings about the newest advancements in interventional radiology.
TOP TEN QUESTIONS ABOUT LIVER-DIRECTED THERAPY, INCLUDING INTRA-ARTERIAL TECHNIQUES & SEQUENCING:
What do patients need to know about bland embolization (TAE)?
a. What are the possible side effects?
b. How do the size of beads play a role?
c. When is this recommended?
d. Do you always do both sides of the liver? If so, what is the timing and why?
e. What is the recovery like? What is post-embolization syndrome?
What do patients need to know about chemoembolization (TACE)?
a. What drug is used & does this go through the whole body?
b. What is the recovery like? What are the possible side effects?
What do patients need to know about radioembolization (TARE, SIRT, y90)?
a. In the era of PRRT, is there a concern with using y90 or radioembolization? How is the approach and techniques used with radioembolization different than how it was done in the past? Is there a total lifetime limit of radiation?
b. What is the recovery like? What are the possible side effects?
Is there a limit to how much LDT one can do? Can they be repeated?
How does one decide between the various types of liver-directed therapies?
Is there a sequencing to treatments?
Are there certain treatments that make you ineligible for other treatments? [PRRT, chemo, y90 etc]
If someone has had surgery such as a Whipple or surgery or procedures involving the bile duct such as a stent in the bile duct or surgical removal of part of the bile duct, how does this weigh into the decision-making process for LDT?
How do you determine if the treatment “worked?” What is the follow up like? What scan might you do and in what timing?
What do you see as the future of liver-directed therapy in neuroendocrine cancer treatment?
RESOURCES
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LACNETS Liver-Directed Therapy Videos
DISCLAIMER
LACNETS Podcasts are created for educational purposes only and do not substitute for medical advice. The views shared in this Podcast are the personal opinions of the experts and do not necessarily reflect the views of LACNETS. Please contact your medical team with questions or concerns about your individual care or treatment.
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